Levacur SC 3% Data Sheet

Presentation
Clear amber broad spectrum anthelmintic solution containing 30 mg/ml levamisole hydrochloride with 0.32 mg/ml elemental selenium plus 0.72 mg/ml elemental cobalt as nutritional supplements.
 
Uses
For the treatment of sheep and cattle infected with mature and developing immature stages of the following levamisole-susceptible nematode worm species:
 
Gastro-intestinal worms
Trichostrongylus spp., Cooperia spp., Ostertagia spp. (except inhibited Ostertagia larvae in cattle), Haemonchus spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp.
 
Lungworms
Dictyocaulus spp.
Levacur SC 3% is not effective against Type II winter scour.
Levacur SC 3% also contains selenium and cobalt as nutritional supplements.
 
Dosage and administration
For oral administration only.
 
Sheep
2.5ml per 10kg bodyweight (7.5mg levamisole hydrochloride per kg bodyweight). For example:
Bodyweight
Dose
10 kg
2.5 ml
20 kg
5.0 ml
30 kg
7.5 ml
40 kg
10.0 ml
50 kg
12.5 ml
60 kg
15.0 ml
Sheep over 60 kg should be given a further 1 ml for each additional 4 kg body weight.
 
Cattle
2.5ml per 10kg bodyweight (7.5mg levamisole hydrochloride per kg bodyweight), up to a maximum of 75ml for cattle weighing 300kg and over. For example:
Bodyweight
Dose
50 kg
12.5 ml
100 kg
25.0 ml
150 kg
37.5 ml
200 kg
50.0 ml
250 kg
62.5 ml
300 kg and over
75.0 ml
Veterinary advice should be sought:
- On appropriate dosing programmes and stock management to achieve adequate parasite control, and to reduce the likelihood of anthelmintic resistance developing.
-If the product does not achieve the desired clinical effect, since other diseases, nutritional disturbances or anthelmintic resistance may be involved.
To ensure administration of a correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked. Occasionally at the recommended dose cattle may show signs of lip-licking and slight muscle tremor. Do not mix with other products.
 
Contra-indications, warnings, etc
Animals must not be treated within a period of 14 days before or after treatment with organophosphorus compounds or diethylcarbamazine citrate.
The product may be given to young, pregnant and lactating animals, but due regard must always be paid to the animal's physical condition and the presence of inter-current diseases.
When a dosing gun is used to administer the product, care should be taken to avoid the occurrence of dosing gun pharyngitis.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to levamisole has been reported in Teladorsagia, Cooperia and Trichostrongylus species in sheep in a number of countries, including the EU. There are reports of resistance in Haemonchus in sheep outside the EU. Resistance to levamisole has been reported in Teladorsagia species in cattle in developed countries such as New Zealand. Therefore the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.
At normal therapeutic dosage side effects are rarely seen. Overdosage may occasionally result in the appearance of cholinergic-type symptoms such as salivation, muscular tremors and head shaking. These effects are more likely to be observed in cattle than in sheep.
Do not administer other cobalt and selenium supplements concurrently unless specifically advised by your veterinary surgeon. Not to be diluted.
 
Withdrawal periods
Levacur SC 3% must not be used in animals producing milk for human consumption. Animals must not be slaughtered for human consumption during treatment. Sheep and cattle may be slaughtered for human consumption only after 20 days from last treatment.
 
Operator warnings
When using, do not eat, drink or smoke. Wash splashes from eyes and skin immediately. Remove any contaminated clothing immediately. Wash hands and exposed skin before meals and after work. Levamisole can cause idiosyncratic reactions and serious blood disorders in a very small number of people.
If symptoms such as dizziness, nausea, vomiting or abdominal discomfort are experienced when using this product, or sore mouth/throat or fever occur shortly afterwards, then medical advice should be sought immediately.
For animal treatment only. Keep out of the reach and sight of children.
 
Pharmaceutical precautions
Do not store above 25°C. Store in the original container. Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
 
Legal category
POM-VPS
 
Packaging Quantities
2.5, 5 and 10 litre multidose containers.
 
Further information
Nil
 
Marketing authorisation number
Vm 01708/4488.