Mesalin solution for injection Data Sheet

Presentation

A clear, oily, sterile solution for injection containing 0.2 mg/ml estradiol benzoate in arachis oil.

Uses

Mesalin is indicated solely for the prevention of pregnancy following mismating (mesalliance) in the bitch.

Dosage and administration

Dosage
0.01 mg/kg (0.5 ml/10 kg) to be given on the 3rd and 5th day after mating (day of mating is day 0).
A third dose may be administered 7 days after mating if circumstances dictate e.g. if the bitch has been observed to have been mated several times or where the timing of the unwanted mating is unknown.
Administer by subcutaneous or intramuscular injection. The product does not contain an antimicrobial preservative. Swab the septum prior to removal of each dose. Use a dry sterile needle and syringe.

Contra-indications, warnings, etc.

Mesalin should not be administered to cats.

Care should be taken to avoid accidental self-injection.

If accidental self -injection occurs, seek medical advice immediately and show the doctor this label.

Wash hands after use. 

FOR ANIMAL TREATMENT ONLY.  KEEP OUT OF REACH AND SIGHT OF CHILDREN.

Pharmaceutical precautions

Do not store above 25°C. Protect from light.
Keep container in outer carton.
At a low temperature the product may become viscous. Warming the vial in the hand will restore the contents to the normal state.

Following withdrawal of the first dose, use the product within 28 days. Discard unused material. When the container is broached for the first time, use the in-use shelf life which is specified on the package leaflet to calculate the date on which any remaining product shall be discarded. This discard date should be written in the space provided on the label.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Legal category

POM-V                     To be supplied only on veterinary prescription.

Package quantities

5 ml vials

Further information

Large doses of oestrogens have been associated in the dog with blood dyscrasias and pathological changes in the uterus. Mesalin has been formulated to facilitate the administration of a low but effective dose of estradiol benzoate to help to minimise the occurrence of side effects.
Because the amount of oestrogen given to the bitches is low when Mesalin is used, prolonged oestrus with the risk of further, possibly fertile, matings is largely avoided. False pregnancies, pyometra and vaginal discharges are commonly seen after oestrus in normally cycling unmated bitches and may occur with similar frequency following the administration of Mesalin.

In trial work, pregnancy was found to continue in up to 5% of bitches despite Mesalin treatment. It is suggested that owners are advised accordingly before the treatment is commenced.

Marketing Authorisation number

Vm 01708/4246