Nobivac Pi Data Sheet
Presentation
Live, attenuated, freeze dried virus vaccine containing canine parainfluenza virus (CPi) strain Cornell at least 5.5 log TCID50 per dose, and traces of antibiotics (neomycin, polymyxin B, gentamycin or amphotericin B) as remnant from the antigen production.
Each vial contains a single dose for reconstitution prior to use.
Uses
For active immunisation of dogs from the age of 8 weeks onward to reduce clinical signs of canine parainfluenza infection and to reduce viral shedding.
Dosage and administration
One ml solvent (Nobivac Solvent, Nobivac Lepto 2 (canine leptospirosis vaccine) or Nobivac Rabies) must be used to reconstitute the freeze-dried Nobivac Pi vaccine. After reconstitution, the vaccine should be used within 30 minutes.
One ml of the reconstituted vaccine should be given by subcutaneous injection.
Sterile equipment should be used for administration but avoid contamination of vaccine with traces of disinfectant or spirit.
Primary course vaccination
• Before the age of 12 weeks:
Two vaccinations, each with a single dose: the first vaccination from the age of 8 weeks onwards and the second vaccination 2-4 weeks later.
• From the age of 12 weeks onwards: single vaccination, with one dose per animal.
Onset of immunity: 4 weeks after vaccination.
Booster vaccination
Annually with a single dose.
The normally recommended vaccination regime using Nobivac DHPPi, Lepto 2, Pi and KC would be as follows:
6-8 weeks Nobivac DHPPi + Nobivac Lepto 2
10 weeks Nobivac DHPPi + Nobivac Lepto 2
1st annual booster Nobivac DHPPi + Nobivac Lepto 2
2nd annual booster Nobivac Pi + Nobivac Lepto 2
3rd annual booster Nobivac Pi + Nobivac Lepto 2
4th annual booster Nobivac DHPPi + Nobivac Lepto 2
5th annual booster Nobivac Pi + Nobivac Lepto 2
6th annual booster Nobivac Pi + Nobivac Lepto 2
7th annual booster Nobivac DHPPi + Nobivac Lepto 2
etc.
Prior to any period of increased risk from canine parainfluenza virus infection:
Nobivac Pi or Nobivac KC.
Prior to any period of increased risk from canine bordetellosis or ‘kennel cough’ of unknown aetiology:
Nobivac KC.
Contra-indications, warnings etc.
Only healthy dogs should be vaccinated.
Nobivac Pi has been shown to be safe for use in pregnant bitches that have previously been vaccinated with a Nobivac vaccine containing the Pi component.
Some dogs may show discomfort during injection.
A diffuse swelling, up to 5 mm in diameter, may be observed at the site of injection. Occasionally this swelling may be hard and painful and last for up to 3 days post injection.
After subcutaneous administration with Nobivac Lepto 2 or Nobivac Rabies, a diffuse swelling may be observed at the injection site in most puppies. Occasionally this swelling may be hard and painful but this will diminish gradually and disappear after 2-3 weeks.
In the rare event of a hypersensitivity reaction following vaccination, administer an antihistamine, corticosteroid or adrenaline, without delay and by the most immediate route.
FOR ANIMAL TREATMENT ONLY. KEEP OUR OF REACH AND SIGHT OF CHILDREN.
Pharmaceutical precautions
Store in original package at 2-8°C (in a refrigerator). Do not freeze. Protect from light. Care should be taken to avoid prolonged or repetitive exposure to high ambient temperatures following withdrawal from the refrigerator prior to use.
In the case of accidental self-injection, seek medical advice immediately and show the package insert or the label to the physician.
Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant, in accordance with national requirements.
Legal category
POM-V To be supplied only on veterinary prescription.
Package quantities
Cartons of 10 and 50 single dose vials.
Not all presentations may be marketed.
Further information
No information is available on the concurrent use of this vaccine with any other, except the leptospirosis and/or rabies vaccines of the Nobivac series. When immunisation is a part of a comprehensive vaccination programme these liquid vaccines can be used to reconstitute the freeze-dried Nobivac Pi. It is recommended that no other vaccines should be administered within 14 days before or after vaccination with Nobivac Pi.
Duration of immunity has not been demonstrated, but an anamnestic response is produced in dogs given a revaccination one year after basic vaccination.
As maternally derived passive antibody can interfere with the response to vaccination in very young animals, a final dose at 10 weeks of age or older is recommended.
A protective antibody titre is not accomplished in all vaccinated dogs.
A good immune response is reliant on the reaction of an immunogenic agent and a fully competent immune system. Immunogenicity of the vaccine antigen will be reduced by poor storage or inappropriate administration. Immunocompetence of the animal may be compromised by a variety of factors including poor health, nutritional status, genetic factors, concurrent drug therapy and stress.
Marketing Authorisation number
Vm 06376/4034 UK authorised veterinary medicinal product.
