Do not use in dogs that have been treated with immunosuppressive drugs or hyperimmune serum within the last month.
No information is available on the use of the vaccine in pregnant bitches. Do not use in pregnant or lactating bitches. Pregnant bitches should not come into contact with recently vaccinated animals.
Following primary vaccination, dogs should remain isolated from possible sources of infection for at least 7 days to reduce risk of interference with the immune response.
The presence of maternally derived antibodies (MDA) in young puppies may interfere with the development of a protective immune response following vaccination. Nevertheless, the vaccine has been demonstrated to be efficacious in puppies with moderate levels of MDA to canine distemper virus (CDV), canine parvovirus (CPV), and canine adenovirus (CAV). Intramuscular vaccination gives a slightly higher serological response than subcutaneous vaccination. Thus, if particularly high and persistent levels of MDA against CPV or CDV are suspected or measured (e.g. for CDV >30 units SN at first vaccination) then intramuscular vaccination is recommended and the first vaccination should be delayed to 8 weeks of age.
Following vaccination, the vaccine viruses CAV-2 and CPV will be excreted and can spread to unvaccinated animals in contact but will not cause disease. Canine parainfluenza (CPi) may also be excreted but will not spread.
Cats (a non-target species) are known to be susceptible to CPV, and therefore in-contact animals may develop antibodies but not disease.
Avoid intradermal vaccination.
A mild (<1 cm3), transient, local swelling may infrequently be seen at the injection site after the first intramuscular vaccination, which resolves completely without complication within a maximum of 3 weeks. Swelling commonly occurs at the injection site after the first or second subcutaneous vaccination; this swelling was up to 7.7 cm3 (4 cm diameter) after the first vaccination and resolved within 2 weeks without complication. In rare cases the swelling may be severe. In rare cases diarrhoea may be observed after vaccination and after intramuscular vaccination a single case (1%) of transient (1-2 day duration) lameness was observed.
Occasional hypersensitivity reactions may rarely occur. In such cases appropriate treatment, such as adrenaline or antihistamine, should be administered without delay. Dogs which receive an overdose of vaccine will exhibit similar adverse effects as described above. Local swelling at the injection site (particularly when subcutaneous injection is used) may be larger (up to 10.7 cm3) and take longer to resolve (up to 33 days).
Interactions
No information is available on the safety and efficacy from the concurrent use of this vaccine with any other. It is therefore recommended that no other vaccines should be administered within 14 days before or after vaccination with the product.
Do not mix with any other vaccine/immunological product.
Operator warnings
In the case of accidental self-injection or ingestion seek medical advice immediately and show the package leaflet or label to the physician.
Withdrawal period
Not applicable.
For animal treatment only. Keep out of reach and sight of children.
