Rapinovet Product Data Sheet

Presentation
A white, aqueous, isotonic emulsion for intravenous injection, containing 10 mg propofol Ph Eur per ml.

Uses
A short-acting, intravenous, general anaesthetic for procedures of short duration, lasting up to five minutes.
For induction and maintenance of general anaesthesia using incremental doses to effect.
For induction of general anaesthesia where maintenance is provided by inhalation anaesthetics.
Rapinovet is particularly suitable for cases where a short recovery period is desired

Dosage and administration
Dose
Induction: The induction dose is computed according to bodyweight and may be administered to effect over a period of 10-40 seconds. Alternatively, the computed dose may be given in full as a single bolus. The induction dose is reduced by the use of premedicants.
It should be noted that the dose rates shown are for guidance and in practice the dose rate should be based on reponse. The average induction dose for dogs and cats, either unpremedicated or when premedicated with a tranquilliser such as acepromazine, is as follows:

Maintenance by Rapinovet
Where anaesthesia is maintained by incremental injections, the dose rate will vary between animals. Incremental doses should be given to effect. Experience in clinical trials has shown that doses of around 1 ml per 4.0–8.0 kg bodyweight sustain anaesthesia for periods of up to five minutes.

Maintenance by inhalation agents
Where inhalation agents are used to maintain general anaesthesia, clinical experience indicates that there may be a need to use a higher initial concentration of inhalation agent than is normally the case following induction with barbiturate agents such as thiopentone.

Administration
By intravenous injection. The vial should be shaken thoroughly before use. The emulsion should not be mixed with other therapeutic agents or infusion fluids prior to administration.

Contra-indications, warnings, etc
Contra-indications
None.

Warnings
During induction of anaesthesia, mild hypotension and transient apnoea, similar to effects with other intravenous anaesthetic agents, may occur. When using Rapinovet, facilities for the maintenance of a patent airway should be available.
As with other potent intravenous anaesthetic agents, caution should be exercised in dogs and cats with cardiac, respiratory, renal or hepatic impairment, or in hypovolaemic or debilitated animals.
Rapinovet has not been used in cats and dogs where the pregnancy is to be maintained, but has been used successfully for induction prior to Caesarean section in bitches.
If Rapinovet is injected very slowly, an inadequate plane of anaesthesia can occur.

Side-effects
Side-effects during induction, maintenance and recovery are uncommon. Induction is generally smooth, with minimal evidence of excitation. During the recovery phase, vomiting and evidence of excitation have been observed in a small proportion of animals.
In clinical trials in cats, transient apnoea during induction and a paw/face licking characteristic during recovery have been observed in a small proportion of cases.
If panting is evident before induction, it may continue throughout the subsequent periods of anaesthesia and recovery.

Overdosage
Accidental overdosage is likely to cause cardio-respiratory depression. Respiratory depression should be treated by artificial ventilation with oxygen. Cardiovascular depression requires the use of plasma expanders and pressor agents.

Operator warnings
This is a potent drug; particular care should be taken to avoid accidental self-administration. Preferably use a guarded needle until the moment of injection.
Wash off splashes from the skin and eyes immediately.
In the event of accidental self-administration
Seek urgent medical attention and show the label to advice doctor.