Bovilis IBR Marker live Product Data Sheet
Presentation
Bovilis IBR Marker live is a live, attenuated marker vaccine per dose containing at least 5.7 log10 TCID50 of gE¯ BHV-1 strain GK/D.
Traces of antibiotics and cell debris can be present as remnant from the antigen production.
Uses
For the active immunisation of cattle to reduce the intensity and duration of the clinical respiratory signs induced by an infection with BHV-1 and to reduce nasal excretion of field virus.
Onset of immunity
An increase in immunity has been demonstrated 4 days after intranasal vaccination and 14 days after intramuscular vaccination of 3 month old seronegative animals.
Duration of immunity
After intranasal administration to 2 week old calves without maternal antibodies, immunity lasts at least until the age of 3-4 months, when the animals should be revaccinated. In the presence of maternally derived antibodies, the protection of the vaccine may not be complete until this revaccination.
Revaccination at 3-4 months of age results in protective immunity that lasts for at least 6 months.
Single intranasal or intramuscular vaccination of 3 months old animals provides protective immunity (reduction of clinical signs and reduction of viral excretion), which has been demonstrated via challenge 3 weeks after vaccination. Reduction of viral excretion is maintained for at least 6 months after single vaccination.
Dosage and administration
Dosage: a single dose of 2 ml reconstituted vaccine per animal.
For intranasal or intramuscular administration.
Reconstitute the vaccine immediately before use with Unisolve (10ml per 5 doses). Inject a few ml of solvent into the vaccine vial and shake gently until the vaccine pellet is completely dissolved. Then transfer the concentrated vaccine to the rest of the solvent and mix well.
Method of administration
- from the age of 3 months onward: intranasal or intramuscular.
- at an age between 2 weeks and 3 months: intranasal
For intranasal administration (1 ml in each nostril), the use of a nozzle is recommended.
VACCINATION SCHEDULE
Basic vaccination
Vaccinate each animal with one single dose.
Revaccination
When the first vaccination is given between the age of 2 weeks and 3 months, the animals should be revaccinated with a single dose at the age of 3-4 months. To maintain immunity, revaccinate every 6 months.
When vaccination is started after the animals are 3 months old, to maintain immunity the animals should be revaccinated with a single dose every 6 months.
When Bovilis IBR Marker live is administered concurrently with Bovilis Bovipast RSP, the products must not be mixed.
Use sterile vaccination equipment free from disinfectants. To prevent the spread of any infective agents, the intranasal equipment should be changed at each animal.
Can be used during pregnancy and lactation.
The presence of maternal antibodies can influence the efficacy of the vaccination. To assess the likely benefit of early vaccination in an individual, it is therefore recommended to ascertain the immune status of calves before vaccination is started.
Contra-indications, warnings, etc.
Do not vaccinate unhealthy animals.
No information is available on the use of this vaccine in breeding bulls.
A slight transient rise in temperature (1°C) can occur up to 5 days post vaccination.
An increase of nasal discharge can be observed after intranasal vaccination.
After intranasal administration, the vaccine virus may spread to in-contact cattle. Cattle which need to remain totally free from all detectable antibodies to BHV-1 should be separated from intranasally vaccinated animals.
No information is available on the safety and efficacy for the concurrent use of this vaccine with any other vaccine except with Bovilis Bovipast RSP. It is therefore recommended that no other vaccines should be administered within 14 days before and after vaccination with this product.
Do not use together with immunosuppressive agents.
User warning
In the case of accidental self-injection, seek medical advice immediately and show the package insert or the label to the physician.
Withdrawal periods
Meat/Milk: Zero days
For animal treatment only. Keep out of THE reach AND SIGHT of children.
Pharmaceutical precautions
Store between +2°C and +8°C in the original packaging.
Reconstituted vaccine should be stored below 25°C and should be used within 3 hours.
Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant in accordance with national requirements.
Legal category
POM-V To be supplied only on veterinary prescription.
Package quantities
5 dose vials packed with 10 ml of solvent.
10 dose vials packed with 20 ml of solvent.
25 dose vials packed with 50 ml of solvent.
50 dose vials packed with 100 ml of solvent.
Further information
Nil.
Marketing Authorisation number
Vm 06376/4032
