Nobilis TRT Live Data Sheet
Presentation
Live, freeze-dried vaccine against turkey rhinotracheitis. Each dose of vaccine contains at least 102.5 TCID50 turkey rhinotracheitis vaccine virus. The vaccine pellet contains stabilizers.
Uses
For the active immunisation of turkeys against turkey rhinotracheitis (TRT) and broilers against the adverse effects of TRT virus infection.
Onset of immunity: 3 weeks after vaccination.
Duration of immunity: 6-9 weeks after vaccination.
Dosage and administration
The vaccine may be administered either by spray or by eyedrop/intranasal application.
Spray method
The vaccine should be dissolved in cool, clean water which is free of iron and chlorine. The appropriate number of vials should be opened under the surface of the water. The volume of water for reconstitution should be sufficient to ensure an even distribution when sprayed onto the birds. This will vary according to the age of the birds being vaccinated and the management system. The vaccine medicated water should be spread evenly over the correct number of birds, at a distance of 30-40 cm (12 – 16”), preferably when the birds are sitting together in dim light. The spray apparatus should be free from sediments, corrosion and traces of disinfectants (and ideally should be used for vaccination purposes only). The sprayer nozzles should be set to deliver a coarse spray.
Eyedrop/Intranasal application
Dissolve the vaccine in water (usually 40 ml per 1000 doses) and administer by means of a dropper. One drop should be applied into one of the nostrils or one eye. The handler should ensure that the nasal drop is inhaled by the bird.
Vaccination programme
The optimum time and method of administration depend largely upon the local situation. Therefore, the advice of a veterinarian should be sought.
The vaccine is recommended for use in turkey poults or broiler chicks from day old.
Contra-indications, warnings, etc.
Do not vaccinate unhealthy birds. Sick or weak birds will not develop adequate immunity following vaccination.
The vaccine should not be used on sites where TRT has not been diagnosed unless challenge is anticipated.
The vaccine virus spreads and shows some reversion to virulence on bird to bird passage. For these reasons its use is not recommended on multi-age sites.
Correct administration is important to ensure optimal initial vaccine ‘take’.
Snicking may be observed after spray vaccination.
At >100 times overdose, day old poults vaccinated by the spray method experienced slight nasal discharge.
Not to be used for birds in lay or within 4 weeks before the onset of the laying period.
Interactions
No information is available on the compatibility of this vaccine with any other. Therefore the safety and efficacy of this product when used with any other (either when used on the same day or at different times) has not been demonstrated.
Do not mix with any other medicinal product.
Operator warnings:
Wash and disinfect hands after vaccinating.
When spraying the vaccine, to avoid hay-fever like reaction in some individuals, well fitting respirator masks, and eye protection, to the appropriate current British/European standard must be worn by the operator and staff.
Withdrawal period:
Zero days.
For animal treatment only. Keep out of the reach and sight of children.
Pharmaceutical precautions
Store between +2°C and +8°C. Do not freeze. Protect from light.
Use within 2 hours of opening vial.
Disposal advice
Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant approved for use by the competent authorities.
Legal category
POM-V To be supplied only on veterinary prescription.
Package quantities
Cartons containing 1 or 10 glass vials (type II Ph.Eur.) containing 1000, 2500 or 5000 doses, closed with a halogenobutyl rubber bung and sealed with a coded aluminium cap.
Not all presentations may be marketed.
Further information
A good immune response is reliant on the reaction of an immunogenic agent and a fully competent immune system. Immunogenicity of the vaccine antigen will be reduced by poor storage or inappropriate administration. Immunocompetence of the animal may be compromised by a variety of factors including poor health, nutritional status, genetic factors, concurrent drug therapy and stress. Under certain conditions, for example extreme disease pressure, fully immune birds may succumb to disease. Therefore, successful vaccination may not be synonymous with full protection in the face of a disease challenge.
Marketing Authorisation number
Vm 01708/4235
Marketing Authorisation holder
Intervet UK Ltd.
Walton Manor, Walton
Milton Keynes, Bucks MK7 7AJ
Distributed in Northern Ireland by:
Intervet Ireland Ltd.
Magna Drive
Magna Business Park
Citywest Road
Dublin 24
Date of text preparation:
January 2008.
Item code: 010010 010010.Dec07/BS/0
