Nasal use. Calves can be vaccinated from the day of birth onwards.

Reconstitute lyophilisate with solvent as described below. Ensure that the lyophilisate is completely reconstituted before use. The reconstituted vaccine is an orange/brown to off-pink or pink coloured suspension.
 
Administer a single dose of 2 ml reconstituted vaccine per animal in one nostril.

Instructions for reconstitution:

1 and 5 dose presentations:

For proper reconstitution of the lyophilisate, transfer the solvent to the vial with the lyophilisate (2 ml for the 1 dose, 10 ml for the 5 dose; also see the table below) using a needle and syringe. The vacuum in the vaccine vial will allow quick emptying of the syringe. Then resuspend by shaking. The vaccine suspension can be drawn up in a syringe with a clean tip. The vaccine in the syringe is now ready for administration, directly from the tip of the syringe. A spraying device is not required.

10 and 20 dose presentations:

For proper reconstitution of the lyophilisate, transfer 10 ml of the solvent to the vial with the lyophilisate using a needle and syringe. The vacuum in the vaccine vial will allow quick emptying of the syringe. Then resuspend by shaking. Completely draw up the vaccine suspension and transfer it back to the solvent vial in order to get the correct dose/volume ratio for the respective presentation (20 ml for the 10 dose, 40 ml for the 20 dose; also see the table below). The vaccine suspension can be drawn up in a syringe with a clean tip. The vaccine in the syringe is now ready for administration, directly from the tip of the syringe. A spraying device is not required. When vaccinating animals, it is recommended to change syringes or tips of a multidose syringe between animals to avoid transmission of pathogens.

Doses per vial	Solvent volume required	Dose volume
1	2	2 ml
5	10	2 ml
10	20	2 ml
20	40	2 ml

Bovilis INtranasal RSP Live Reconstitution and Application Instructions: